Translational Physiology Kidney plays a major role in ammonia homeostasis after portasystemic shunting in patients with cirrhosis
نویسندگان
چکیده
Steven W. M. Olde Damink, Cornelis H. C. Dejong, Nicolaas E. P. Deutz, Doris N. Redhead, Peter C. Hayes, Peter B. Soeters, and Rajiv Jalan Department of Surgery, Maastricht University, Maastricht, The Netherlands; Liver Unit, Department of Surgery and Radiology, Royal Infirmary of Edinburgh, Edinburgh, Scotland, United Kingdom; and Liver Failure Group, Institute of Hepatology, Royal Free and University College Medical School, University College London, London, United Kingdom
منابع مشابه
Kidney plays a major role in ammonia homeostasis after portasystemic shunting in patients with cirrhosis.
The kidney plays an important role in ammonia metabolism. In this study the hypothesis was tested that the kidney can acutely diminish ammonia release after portacaval shunting. Thirteen patients with cirrhosis (6 female/7 male, age 54.4 +/- 3.3 yr) were studied. Blood was sampled prior to and 1 h after transjugular intrahepatic stent-shunt (TIPSS) insertion from the portal vein, a hepatic vein...
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The effect of liver disease on glucagon metabolism was examined in nine patients with chronic liver disease who were studied both before and after the creation of a surgical portasystemic shunt. Hepatocellular function did not deteriorate after shunt surgery. However, hepatic perfusion with splanchnic venous blood, as determined by scintisplenoportography, decreased after shunt surgery in six s...
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The gut is classically seen as the main source of circulating ammonia. However, the contribution of the intestines to systemic ammonia production may be limited by hepatic extraction of portal-derived ammonia. Recent data suggest that the kidney may be more important than the gut for systemic ammonia production. The aim of this study was to quantify the role of the kidney, intestines, and liver...
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During liver insufficiency, besides portasystemic shunting, high arterial glutamine concentrations could enhance intestinal glutamine consumption and ammonia generation, thereby aggravating hyperammonaemia. To investigate this hypothesis, portal drained viscera (intestines) fluxes and jejunal tissue concentrations of ammonia and glutamine were measured in portacaval shunted rats with a ligated ...
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Objective(s) The liver has major role in the organism homeostasis, interactions with other systems, synthesis and metabolism of bile production, drug detoxification and hormone inactivation. Cholestasis can be defined as an impairment of the bile flow which can lead to hepatocytes necrosis and finally cirrhosis. Some studies reported a gastric acid secretion reduction in cirrhotic subjects, wh...
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